Dental pulp contains multipotent mesenchymal stem cells.
- Mesenchymal stem cells help repair hearts damaged by heart attack by becoming heart cells themselves.
- Autologous Mesenchymal Stem Cell Therapy Delays the Progression of Neurological Deficits in Patients With Multiple System Atrophy.
- Mesenchymal Stem Cell Transplantation Accelerates Hearing Recovery through the Repair of Injured Cochlear Fibrocytes.
- Mesenchymal stem cells have shown therapeutic potential in prostate cancer bone metastasis (Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama)
- Clinical applications of human Mesenchymal Stem Cells are evolving rapidly with the aim to improve hematopoietic engraftment, preventing graft-versus-host disease (GVHD), correcting inborn metabolic errors and delivering a variety of therapeutic genes into the cells.
Applications of mesenchymal stem cells in tissue engineering and regenerative medicine
- Mesenchymal stem cells have been used to regenerate marrow microenvironment after myeloablative therapy.
- The use of natural and synthetic biomaterials as carriers for mesenchymal stem cells delivery has shown increasing promise for orthopedic therapeutic applications, especially bone formation. Mesenchymal stem cells are ideal for treating arthritis and connective tissue ailments.
- When introduced into the infarcted heart, mesenchymal stem cells prevent deleterious remodeling and improve recovery.
- Number of reports have also indicated that these cells possess the capacity to trans-differentiate into epithelial cells and lineages derived from the neuro-ectoderm, and in addition, mesenchymal stem cells can migrate to the sites of injury, inflammation and to tumors. These properties of mesenchymal stem cells make them promising candidates for use in regenerative medicine and may also serve as efficient delivery vehicles in site-specific therapy.
Future Research on Mesenchymal Stem Cells
- According to American Diabetes Association, mesenchymal stem cells can be the key to healing diabetic foot ulcers: Diabetic foot ulcers are the primary cause of hospital admissions for diabetics. Foot ulcers that heal improperly are at risk for infection, which can lead to amputation.